Originally posted by minestrone
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The combined vaccine is significantly more likely to lead to problems with people who are immuno compromised. Advice is (or was when my kids were of that age) that immuno suppressed people should not be given the MMR jab. Also children in households with immuno suppressed people should not be given it (possibility of additional risk to the immuno suppressed person).
Whether the overall risk to the patient is any different than the additional risk factors caused by 3 separate live vaccinations I don't know; it is almost certainly the case that the combined vaccine is probably the correct choice for most people, but for a small minority it definitely isn't.
Edit, think the advice is still current.
http://www.mmrthefacts.nhs.uk/resour.../MMRII_SPC.pdf
An extract:-
Fatal cases of measles inclusion body encephalitis (MIBE) and pneumonitis as a direct consequence of disseminated measles vaccine virus infection have been reported in severely immunocompromised individuals vaccinated with measles-containing vaccine.Those patients with a family history of congenital hereditary immunodeficiency until their immune competence has been demonstrated.


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