DOOM: Covid-19: Oxford University vaccine shows 70% protection

[AtW]

So in your world, 70% is "the top end" of 30-60%? 70% is a very good result.

70% is average from two distinct approaches here: one is 90%+ (which is great), and another is 62% (which is top end of flu vaccine).

Maybe it makes medical sense for half doze/full doze work better than two full dozes, but it seems that organisers of the trial were surprised also.

SARS2 is much more infectious than flu, we need far more than 62% efficacy, especially given growing number of Mor Ons who won't take any vaccine.

[AtW]

“ Maxim Jacobs, of the investment research firm Edison Group, said: “It’s not normal for there to be lower efficacy for a higher dose, it can happen but it’s rare. There are some potential explanations, such as the vector immune response, but it’s hard to know without more data.””

AstraZeneca shares fall after efficacy findings for Covid-19 vaccine | Business | The Guardian

[AtW]

“ When the vaccine was given as a half dose and then a full dose one month later to about 2,700 participants, it had an efficacy of 90 percent. When given as two full doses at least one month apart to about 8,900 participants, it showed 62 percent efficacy.”

AstraZeneca to seek FDA authorization for vaccine based on foreign trial data - POLITICO

So 90% is in much smaller, pretty small group really - just 2700 participants.

They need to expand trial, it’s too odd result for too small of a group (size can explain odd result).

Won’t be taking this vaccine, unless they clear it up conclusively.

[AtW]

"A dosing error during clinical trials led to the Oxford vaccine reaching 90 per cent efficacy by accident, it has emerged.

In the spring, scientists were left baffled as to why participants were experiencing much milder side effects than expected.

When they checked, they found participants had received just half the dose given to 500 adults in earlier safety trials.

Instead of restarting the trial, researchers at Oxford University boosted the initial participants with a full dose while everyone who enrolled later received the full amount.

Trial results announced on Monday show that the 'correct' vaccine dose achieved just 62 per cent efficacy while the 'accidental' arm was 90 per cent effective."

Dosing error in trials led to Oxford vaccine's 90 per cent efficacy by accident, say scientists

This hardly inspires confidence.

[_V_]

"A dosing error during clinical trials led to the Oxford vaccine reaching 90 per cent efficacy by accident, it has emerged.

In the spring, scientists were left baffled as to why participants were experiencing much milder side effects than expected.

When they checked, they found participants had received just half the dose given to 500 adults in earlier safety trials.

Instead of restarting the trial, researchers at Oxford University boosted the initial participants with a full dose while everyone who enrolled later received the full amount.

Trial results announced on Monday show that the 'correct' vaccine dose achieved just 62 per cent efficacy while the 'accidental' arm was 90 per cent effective."

Dosing error in trials led to Oxford vaccine's 90 per cent efficacy by accident, say scientists

This hardly inspires confidence.

Snake oil.

[AtW]

Further testing is essential - on anti-vaxxers, free tinfoil on 2nd shot

[jayn200]

"A dosing error during clinical trials led to the Oxford vaccine reaching 90 per cent efficacy by accident, it has emerged.

In the spring, scientists were left baffled as to why participants were experiencing much milder side effects than expected.

When they checked, they found participants had received just half the dose given to 500 adults in earlier safety trials.

Instead of restarting the trial, researchers at Oxford University boosted the initial participants with a full dose while everyone who enrolled later received the full amount.

Trial results announced on Monday show that the 'correct' vaccine dose achieved just 62 per cent efficacy while the 'accidental' arm was 90 per cent effective."

Dosing error in trials led to Oxford vaccine's 90 per cent efficacy by accident, say scientists

This hardly inspires confidence.

I think it's quite typical. Mistakes are super common. Just because they are working for some research company doesn't make the person doing whatever job there any more competent than the average office worker you run into on a regular basis and we know how often the average person makes a mistake.

[SueEllen]

"A dosing error during clinical trials led to the Oxford vaccine reaching 90 per cent efficacy by accident, it has emerged.

In the spring, scientists were left baffled as to why participants were experiencing much milder side effects than expected.

When they checked, they found participants had received just half the dose given to 500 adults in earlier safety trials.

Instead of restarting the trial, researchers at Oxford University boosted the initial participants with a full dose while everyone who enrolled later received the full amount.

Trial results announced on Monday show that the 'correct' vaccine dose achieved just 62 per cent efficacy while the 'accidental' arm was 90 per cent effective."

Dosing error in trials led to Oxford vaccine's 90 per cent efficacy by accident, say scientists

This hardly inspires confidence.

I'm inspired by Britain's creativity.

[AtW]

I'm inspired by Britain's creativity.

Yeah, I like Banksy too

[AtW]

“ AstraZeneca and Oxford University on Monday reported that a lower initial dose of the vaccine, followed by a full dose, produced a 90 per cent efficacy rate, compared with 62 per cent for two full doses.

However, Moncef Slaoui, the scientific head of the US's Operation Warp Speed - the programme to supply America with vaccines - told US reporters that the half-dose regime, which was discovered by accident, was only given to adults aged 55 and under - throwing the validity of the results into question.

“Now that we’ve found what looks like a better efficacy we have to validate this, so we need to do an additional study,” chief executive Pascal Soriot told Bloomberg.”

Coronavirus latest news: AstraZeneca may run new global vaccine trial, chief executive says - watch Downing St briefing live

mRNA wins