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Well any system that's a power of 2 (base8, base16) would be a good combination nowadays as it works well with binary, base10 is problematic because of the 1/3rrds and the rounding errors.
Anyway hex would probably be a good choice for humans as it doesn't get too verbose with moderate numbers.
Since we can't even change the silly keyboard layout that we have for 100 years, I don't think that a number migration could happen without nuclear holocaust as a catalyst