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And presumably we're going to need a reference table, and foreign key constraint. This is getting over engineered now

Under sex, just put "Yes please" which is a CHAR(10).

What if you've got all the right bits to be male or female but they are all in the wrong place?
You mean if you're MFs Mother-in-law?
But someone's chromosomes don't indicate how they want to live or more importantly in the office - what toilet they are going to use.

But someone's chromosomes don't indicate how they want to live or more importantly in the office - what toilet they are going to use.
And is the way we label the toilets discriminatory?